Optimization of Following the Lead Content in Metabolism after Intoxication

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  • Z. Dlaskova Chimique of Professional Diseases, 1st Faculty of Medicine, Laboratory of Toxicology,
  • T. Navratil J.Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Prague
  • L. Novotny J.Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Prague
  • D. Pelclova Chimique of Professional Diseases, 1st Faculty of Medicine, Laboratory of Toxicology,
  • P. Madlova Chimique of Professional Diseases, 1st Faculty of Medicine, Laboratory of Toxicology,

Abstrakt

In the present medical practice a poisoning by lead is usually proved by measuring the concentration of Pb (II) ions in blood and urine and by the determination of d-aminolevulic acid (ALA) as well as by a semiquantitative determination of the porphyrines content in urine. The above analytical procedures are time-consuming and relatively expensive. The present communication describes the procedures used for obtaining independent analytical results in following the detoxication of the organism after a lead poisoning. It has been found that the quantity of Pb(II) ions determined in urine and blood and that of d-aminolevulic acid and of porphyrines in urine are not independent. A correlation was e.g. found between the porphyrine and the d-aminolevulic acid content. Thus the determination of one of last-mentioned substances is superfluous. The correlation analysis made it possible to propose a simplification and an acceleration of following the detoxication process in a patient.

Publikováno

15.03.1999

Jak citovat

Dlaskova, Z., Navratil, T., Novotny, L., Pelclova, D., & Madlova, P. (1999). Optimization of Following the Lead Content in Metabolism after Intoxication. Chemické Listy, 93(2). Získáno z http://ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2637

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