Galactosyltransferase Inhibitors

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  • I. Jambal Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
  • K. Kefurt Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
  • J. Moravcová Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague

Abstrakt

Oligosaccharides in glycoconjugates form a sugar code in cell-cell recognition processes. Since galactosyltransferases are responsible for the biosynthesis of galactose-containing oligosaccharides, inhibitors of these enzymes are targets for drug design. In this review, the current state of the development of galactosyltransferase inhibitors, based on the donor and transition-state structures and bisubstrate analogues, is summarised.

Publikováno

15.05.2012

Jak citovat

Jambal, I., Kefurt, K., & Moravcová, J. (2012). Galactosyltransferase Inhibitors. Chemické Listy, 106(4). Získáno z http://ww.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/978

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