Racionální návrh léčiv s využitím farmakoforového modelování

Abstrakt

Development of information technologies in recent decades has facilitated also a great progress in the development of new drugs. Methods of Computer-Aided Drug Design allow us to explore the spatial interaction between the receptor and a potential drug. The review deals with a brief summary of these computational methods and is mainly focused on pharmacophore modelling, one of the modern approaches in drug design that has proved to be a useful tool.